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JRPMS Vol 3, No 3, September 2019, p.83-86

doi: 10.22540/JRPMS-03-083


Mini Review

Malignant giant cell tumor of bone

Emmanouil Neonakis1, Georgia Antoniou1, Ioannis K. Triantafyllopoulos2

  1. “Agia Sofia” General Children’s Hospital, Division of Orthopedic Surgery, Athens, Greece
  2. Laboratory for Research of the Musculoskeletal System, National and Kapodistrian University of Athens, Greece

Keywords: Giant cell tumor, Long bones, Malignant transformation


Giant cell tumors of bone are locally destructive benign entities that occur predominantly in long bones of postpubertal adolescents and young adults. The majority are treated by aggressive curettage or resection. Occasionally, Giant cell tumors of bone may undergo malignant transformation to undifferentiated sarcomas. We report a mini review of malignant GCT of the long bones in order to raise awareness of this entity that may mimic the benign form but is more aggressive with poorer prognosis.