JRPMS Vol 1, No 2, December 2017, p.55-64
doi: 10.22540/JRPMS-01-055
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Original Article
Basic laboratory bone profile in Greek patients with galactose metabolic disorders
Maria Kalogerakou1,2, Kleopatra H. Schulpis1, Artemis Doulgeraki3, George I. Lambrou2,4
- Department of Inborn Errors of Metabolism, Institute of Child Health, “Aghia Sofia” Children’s Hospital, Athens, Greece
- Post Graduate Programme “Metabolic Bone Diseases”, National and Kapodistrian University of Athens, Medical School, Athens, Greece
- Department of Bone and Mineral Metabolism, Institute of Child Health, “Aghia Sofia” Children’s Hospital, Athens, Greece
- First Department of Pediatrics, University of Athens, Choremeio Research Laboratory, National and Kapodistrian University of Athens, Greece
Keywords: Galactosaemia, Vitamin D, Creatinine, BMI, HDL
Abstract
Objective: the investigation of the relationship between different basic biochemical parameters of bone metabolism in galactosaemia patients.
Methods: Study participants included twenty two patients with an average age 7.97±5.1 years, early diagnosed by newborn screening and dietary treated. Serum biochemical factors including calcium, phosphate, magnesium, alkaline phosphatase (ALP), creatinine, albumin, lipidaemic factors, vitamin-D, hemoglobin and ferritin were determined during a routine biochemical physical examination. Z-BMI, Z-Wt and Z-Ht were estimated for the assessment of normal or delayed growth.
Results: Estimated biochemical variables did not demonstrate significant differences between patient groups (e.g. males-females, galactosaemia subtypes). Creatinine manifested lower values whereas ALP manifested highest values as compared to reference ranges. Significant differences were observed with respect to BMI estimates as well as Vitamin D vs. age, body weight vs. height in females. Vitamin D was negatively correlated to creatinine and HDL. Calcium was negatively correlated to creatinine, in all patients.
Conclusion: These findings suggest that there is a place for periodic monitoring of basic biochemical bone profile in galactosaemic patients, in order to detect early subtle changes in bone metabolism.