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JRPMS Vol 7, No 4, December 2023, p.119-124

doi: 10.22540/JRPMS-07-119


Review Article

Association between fibromyalgia and osteoporosis

Maria Giannakopoulou1,2

  1. Second Orthopaedic Department, KAT Trauma Hospital of Athens, Athens, Greece
  2. Postgraduate Program “Metabolic Bone Diseases”, National and Kapodistrian University of Athens, Medical School, Athens, Greece

Keywords: Bone mineral density, Chronic pain, Fibromyalgia, Osteoporosis, Vitamin D


Fibromyalgia (FM) is a condition associated with chronic musculoskeletal pain, fatigue, joint rigidity, sleep interruption, depression and cerebral dysfunction. It is a complicated syndrome with not well-known pathogenesis and only clinical diagnosis at the present. Osteoporosis, however, is described as a skeletal disease, which main characteristics are: (1) reduced strength of the bone which is associated with the loss of skeletal mass and (2) micro-architectural deterioration of the bones, without clinical symptoms-except when fractures occur. In recent years, few studies have addressed the relation between fibromyalgia and osteoporosis. Most studies show that fibromyalgia may lead to an increased possibility of osteoporosis due to low levels of exercise because of the chronic pain. In addition, when Vitamin D levels are measured in patients with firbromyalgia syndrome it seems to be lower than general population. However, results of studies of the bone mineral density (BMD) of these patients are conflicted. In this short review article, we provide current knowledge on the relationship between fibromyalgia and osteoporosis, and in addition we discuss the association between fibromyalgia syndrome (FMS) and low bone mineral mass as shown in previously published papers including for systemic reviews and meta-analysis on these subjects.