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JRPMS Vol 7, No 3, September 2023, p.76-81

doi: 10.22540/JRPMS-07-076


Review Article

A Review of the Role of Platelet-Rich Plasma in Fracture Healing

Panagiotis Ntalaperas1,2, Vasileios S. Nikolaou2,3

  1. 1st Department of Orthopedics, Asklepieio Voulas, Athens, Greece
  2. Postgraduate Program “Metabolic Bone Diseases”, National and Kapodistrian University of Athens, Medical School, Athens, Greece
  3. Orthopedic Department, Konstantopoulion Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece

Keywords: Bone healing, Fracture, Platelet - rich plasma


Fractures are a global health concern affecting millions of people annually, with the elderly being more susceptible. Although the majority of patients with fractures recover, approximately 10% of them, particularly the elderly, encounter difficulties in the healing process. Platelet-rich plasma (PRP) is a concentrated solution of platelets that contain numerous growth factors and other bioactive molecules, which make it effective in promoting tissue repair and regeneration. Additionally, PRP injections can enhance local blood flow and stimulate angiogenesis, which can contribute to better healing outcomes in the treated area. Recent literature reviews suggest that PRP has clinical efficacy in accelerating the fracture healing process, treating delayed unions and non-unions, and serving as an adjuvant method when used alone or in combination with surgical procedures. However, the clinical heterogeneity of the available studies warrants the need for further research with high-quality randomized controlled trials involving a large number of participants to provide appropriate guidelines for PRP use. The present narrative review aims to present the recent data in relation to the effectiveness of the use of the PRP injection technique in the process of bone fracture healing.