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JRPMS Vol 6, No 2, June 2022, p.48-54

doi: 10.22540/JRPMS-06-048


Review Article

Association of the B-complex vitamins with osteoporosis and osteoporotic fractures

Elpida D. Sachinidi

  • Postgarduate Program ‘Metabolic Bone Diseases’, National Kapodistrian University of Athens, Medical School, Greece

Keywords: Fractures, MTHFR, Osteoporosis, RANK, Vitamin B


Osteoporosis is a bone metabolic disease associated with low bone mass and deterioration of bone microarchitecture, thus increasing the risk for potential fractures. There is emerging evidence supporting the role of vitamin B in bone health and the prevention of fractures. In this review we evaluated both observational studies and studies assessing the genetic association of the group of B vitamins with the risk for osteoporosis and osteoporotic fractures. We retrieved 25 relevant studies and according to the results, future research is necessary to determine if dietary intake and supplementation of vitamin b may have a potential influence on osteoporosis and osteoporotic fractures.