JRPMS Vol 6, No 2, June 2022, p.42-47
The role of long non-coding RNAs in bone diseases
Cristina Elena Atudorei1, Eleana Fitsi2, Stavroula Rizou3
- Central Biopathological Laboratory, 1st HD of Athens, Athens, Greece
- General Oncology Hospital of Athens “Agios Savvas”, Greece
- Hellenic Osteoporosis Foundation, Kifisia, Greece
Keywords: Bone, Long Noncoding RNAs, Osteoporosis, Osteoarthritis, Rheumatoid arthritis
Long non-coding RNAs (lncRNAs) have gained great attention in recent years as critical players in bone biology and bone diseases. A growing number of studies have demonstrated that lncRNAs are involved in osteogenic differentiation and thus serve a pivotal role in the process of occurrence and progression of bone-related diseases. Dysregulation of their expression seem to be implicated in skeletal tissue abnormalities, This article reviews the importance of lncRNAs in the cellular and molecular mechanisms of bone development, their regulatory role in tissue differentiation and in bone cells and we will highlight potential biomarkers and therapeutic targets for the treatment of bone diseases.