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JRPMS Vol 6, No 1, March 2022, p.14-19

doi: 10.22540/JRPMS-06-014


Case Report

Primary Multi Drug Resistant Tuberculosis (MDR TB) Osteomyelitis in Sternum associated with Xeroderma Pigmentosa: A Case Report

Arvind Vatkar1, Sachin Y. Kale1, Shivam Mehra1, Pramod Bhor2, Aditya Gunjotikar1, Nikhil R. Isaacs1

  1. Department of Orthopaedics, Padmashree Dr. D. Y. Patil School of Medicine, Nerul, Navi Mumbai
  2. Terna Medical College, Nerul, Navi Mumbai

Keywords: Immunodeficiency, Multidrug resistant Tuberculosis, Pectoral muscle cold abscess, Xeroderma Pigmentosa


Xeroderma Pigmentosa (XP) is an autosomal recessive genetic disorder which causes defective gene repair. This makes XP patients cancer-prone and immunodeficient. A 10-year-old male child with XP was infected with MDR Tubercular Osteomyelitis of sternum. He had constitutional symptoms of TB like weight loss and loss of appetite. He had also developed an abscess in his right pectoral muscles. MRI was done to find out exact location and spread of infection. The abscess was aspirated by Z technique and sent for a Gene Xpert test. Patient was started on second line of anti-tubercular therapy. MDR TB is a growing challenge to treat with anti-tubercular therapy. The link of genetic disorders like XP and infections like TB (which increase in immuno-deficient subjects) needs to be studied further.