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JRPMS Vol 5, No 1, March 2021, p.35-40

doi: 10.22540/JRPMS-05-035

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Οriginal Article

Comparison of functional outcomes between teriparatide and vitamin D3 in distal end radius fractures of osteoporotic patients

Prakash D. Samant1, Rohit M. Sane1, Rajendraprasad R. Butala1, Aditya M. Sane2

  1. Department of Orthopaedics, D Y Patil University School of Medicine, Navi Mumbai, Maharashtra, India
  2. Department of Radiology, D Y Patil University School of Medicine, Navi Mumbai, Maharashtra, India

Keywords: Distal end radius fracture, Functional Outcome, Osteoporosis, Teriparatide, Vitamin D3

Abstract

Objectives: The objective of this study was to evaluate and compare the efficacy of teriparatide (osteoanabolic agent) versus vitamin D3 supplementation to improve functional outcomes in osteoporotic patients with distal end radius fractures (DERF). Methods: We conducted a prospective, randomized clinical study to compare the functional outcomes. Sixty osteoporotic DERF patients, treated with either conservative or surgical management were randomized to receive either teriparatide (20 mcg/day) or vitamin D3 (1000 IU/day) for a period of 3 months, along with calcium (500 mg/day) supplementation. The treatment outcomes were evaluated pre and post-management (1-month and 3-months) by Green and O’Brien scale, Patient-rated Wrist Evaluation (PRWE) scale, and Sarmiento scale. Results: There was a significant difference between the two groups at 3-months post-management. Teriparatide showed a significantly greater improvement of functional outcome (P=0.036) and patient-reported outcome (P<0.001) in comparison to vitamin D3 in total Green and O’Brien score and PRWE score, respectively. Conclusion: Teriparatide supplementation was effective and resulted in greater improvement in functional and radiologic outcomes in comparison to vitamin D3. Adjuvant teriparatide therapy may be a therapeutic option to improve the functional outcomes in DERF of osteoporotic patients.