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JRPMS Vol 3, No 2, June 2019, p.45-51

doi: 10.22540/JRPMS-03-045

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Review Article

The role of miRNAs in ankylosing spondylitis: a narrative review

George E. Diakos1,2 and George I. Lambrou1,2,3

  1. Laboratory for Research of the Musculoskeletal System “Th. Garofalidis”, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens KAT, Greece
  2. Postgraduate Program “Metabolic Bones Diseases”, National and Kapodistrian University of Athens, Medical School, Goudi, Athens, Greece
  3. First Department of Pediatrics, National and Kapodistrian University of Athens, Choremeio Research Laboratory, Goudi, Athens, Greece

Keywords: Ankylosing spondylitis, microRNAs, HLA-B27, SNPs


Abstract

Ankylosing Spondylitis (AS) is a chronic, autoimmune inflammatory disease mainly affecting the axial skeleton and it might lead to functional and structural impairments and cause severe disability, thus, jeopardize quality of life. The last two decades, the potential role of miRNAs in the pathogenesis of AS has been under investigation in numerous studies. The aim of this article is to review the available literature on the involvement of miRNAs in AS pathogenesis. An electronic literature search was conducted by two independent researchers up to 2013. Titles and abstracts of papers were validated by the authors for further inclusion in the present work. At the end, full texts of the included articles were retrieved. SNPs of miRNAs lead to an overexpression of pro-inflammatory cytokines. Deregulated miRNAs enhance the production of pro-inflammatory cytokines, suppress autophagy in T peripheral cells of the blood. MiRNAs through a vast number of research have a potential correlation with AS pathogenesis. Because of their stable structure which easily could be extracted from cells of blood samples, the different expressed levels of miRNAs in peripheral blood and tissues from the joints could be used as potential biomarkers of the activity and the efficacy of the treatment in AS.