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JRPMS Vol 1, No 2, December 2017, p.55-64

doi: 10.22540/JRPMS-01-055


Original Article

Basic laboratory bone profile in Greek patients with galactose metabolic disorders

Maria Kalogerakou1,2, Kleopatra H. Schulpis1, Artemis Doulgeraki3, George I. Lambrou2,4

  1. Department of Inborn Errors of Metabolism, Institute of Child Health, “Aghia Sofia” Children’s Hospital, Athens, Greece
  2. Post Graduate Programme “Metabolic Bone Diseases”, National and Kapodistrian University of Athens, Medical School, Athens, Greece
  3. Department of Bone and Mineral Metabolism, Institute of Child Health, “Aghia Sofia” Children’s Hospital, Athens, Greece
  4. First Department of Pediatrics, University of Athens, Choremeio Research Laboratory, National and Kapodistrian University of Athens, Greece

Keywords: Galactosaemia, Vitamin D, Creatinine, BMI, HDL


Objective: the investigation of the relationship between different basic biochemical parameters of bone metabolism in galactosaemia patients. Methods: Study participants included twenty two patients with an average age 7.97±5.1 years, early diagnosed by newborn screening and dietary treated. Serum biochemical factors including calcium, phosphate, magnesium, alkaline phosphatase (ALP), creatinine, albumin, lipidaemic factors, vitamin-D, hemoglobin and ferritin were determined during a routine biochemical physical examination. Z-BMI, Z-Wt and Z-Ht were estimated for the assessment of normal or delayed growth. Results: Estimated biochemical variables did not demonstrate significant differences between patient groups (e.g. males-females, galactosaemia subtypes). Creatinine manifested lower values whereas ALP manifested highest values as compared to reference ranges. Significant differences were observed with respect to BMI estimates as well as Vitamin D vs. age, body weight vs. height in females. Vitamin D was negatively correlated to creatinine and HDL. Calcium was negatively correlated to creatinine, in all patients. Conclusion: These findings suggest that there is a place for periodic monitoring of basic biochemical bone profile in galactosaemic patients, in order to detect early subtle changes in bone metabolism.