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JRPMS Vol 1, No 2, December 2017, p.31-37

doi: 10.22540/JRPMS-01-031


Original Article

Circadian clock mechanisms in adrenal adenomas are not related to osteopenia and osteoporosis

Konstantinos Katsoulis1, Dimitrios Ioannidis1, Georgios Karageorgos1, George I. Lambrou2

  1. Department of Endocrinology, Diabetes and Metabolism,“Amalia Fleming” General Hospital, Athens, Greece
  2. First Department of Pediatrics, University of Athens, Choremeio Research Laboratory,National and Kapodistrian University of Athens, Greece

Keywords: Οsteopenia, Οsteoporosis, Αdenoma, Cortisol, Circadian rhythm


Background: It is known that humans live under the strong influence of light/dark cycles associated with the day/night changes created by the 24-hour rotation of the earth. Yet, it is possible that the circadian rhythm could be disrupted from the presence of a disease and/or changes in body homeostasis. The aim of the present study was to search for an association in patients with adrenal adenomas between cortisol circadian rhythm and osteopathies. Materials and Methods: Twenty eight patients with a history of adenoma, osteopathy or both participated. Patients were tested for routine biochemical factors as well as cortisol levels at 8 a.m., 1 p.m., 5 p.m. and 11 p.m., as well as ACTH and urine cortisol. Results: Significant differences were observed in SGOT levels Free-T4, FSH and K+ in subjects with and without any history of osteopenia or osteoporosis manifesting lower levels as compared to subjects with a history of osteopenia or osteoporosis. At the same time cortisol remained similar among all patient groups. Discussion: Although there is no conclusive evidence, cortisol levels appear to remain untouched by the disease states and thus it appears that circadian rhythms are regulated through an alternative circuitry.